- Easley
- East Gaffney
- East Sumter
- Edgefield
- Edisto
- Edisto Beach
- Ehrhardt
- Elloree
- Elgin
- Eastover
- Elko
- Elgin
- Estill
- Eureka Mills
- Eutawville
- Eadytown
- Eagle Crest
- Eagle Island
- Eagle Point
- Earle
- Earles Grove
- Earlwood Park
- Early Branch
- Earlys Crossroads
- East Gantt
- East Gate Village
- East Lake
- East Shore
- East Spartanburg
- East View