S
- (Overberg District Municipality) Sanbona Wildlife Reserve
- (Overberg District Municipality) Suurbraak
- (West Coast District Municipality) Strandfontein
- (City of Cape Town) Sir Lowry's Pass
- (West Coast District Municipality) South Africa
- (Overberg District Municipality) Struisbaai
- (Cape Winelands District Municipality) Simondium
- (Overberg District Municipality) Sand Bay
- (City of Cape Town) Somerset West
- (West Coast District Municipality) Saint Helena Bay
- (City of Cape Town) Saint James
- (Overberg District Municipality) Sandbaai
- (City of Cape Town) Sonnendal
- (Overberg District Municipality) Stormsvlei
- (Cape Winelands District Municipality) Stockville
- (Eden District Municipality) Still Bay
- (Eden District Municipality) Standplaas
- (Overberg District Municipality) Spitskop
- (Eden District Municipality) Sonskyn
- (Overberg District Municipality) Skipskop
- (Eden District Municipality) Skilpadgat
- (Eden District Municipality) Sheepwalk
- (Central Karoo District Municipality) Seweweekspoort
- (Eden District Municipality) Sedgefield
- (Eden District Municipality) Schoemanshoek
- (Cape Winelands District Municipality) Scheepersrus
- (Eden District Municipality) Sandhoogte
- (Eden District Municipality) Saasveld
- (City of Cape Town) Springbok
- (Cape Winelands District Municipality) Swiss Farm