S
- (Nelson Mandela Bay Metropolitan Municipality) Scotswood
- (Amathole District Municipality) Schoongozicht
- (Joe Gqabi District Municipality) Schoonbeeksfontein
- (Chris Hani District Municipality) Schoombee
- (Chris Hani District Municipality) Schoemanskraal
- (Joe Gqabi District Municipality) Schalkwykskraal
- (Chris Hani District Municipality) Schaapkraal
- (Chris Hani District Municipality) Sawutiya
- (Sarah Baartman District Municipality) Sardinia Bay
- (Joe Gqabi District Municipality) Sapulandake
- (OR Tambo District Municipality) Sapompolo
- (Alfred Nzo District Municipality) Saphukanduka
- (Alfred Nzo District Municipality) Saphukanduka
- (Alfred Nzo District Municipality) Santombe
- (OR Tambo District Municipality) Sangqu
- (OR Tambo District Municipality) Sangoni
- (Chris Hani District Municipality) Sandvlei
- (Sarah Baartman District Municipality) Sandvlakte
- (Alfred Nzo District Municipality) Sandokazi
- (Sarah Baartman District Municipality) Sandland
- (Sarah Baartman District Municipality) Sandkraalspoort
- (Buffalo City Metropolitan Municipality) Sandile
- (Sarah Baartman District Municipality) Sanddrif
- (Sarah Baartman District Municipality) Salem
- (Joe Gqabi District Municipality) Sakute
- (Chris Hani District Municipality) Saint Patrick’s
- (Chris Hani District Municipality) Saint Michaels Mission
- (Joe Gqabi District Municipality) Saint Michael’s
- (Amathole District Municipality) Saint Matthews
- (Chris Hani District Municipality) Saint Mark’s