- Eagles Mere
- Eagleville
- East Berlin
- East Berwick
- East Brady
- East Butler
- East Conemaugh
- East Greenville
- East Lansdowne
- East McKeesport
- East Norriton
- East Petersburg
- East Pittsburgh
- East Prospect
- East Side
- East Stroudsburg
- East Uniontown
- East Vandergrift
- East Washington
- East York
- Eastlawn Gardens
- Eastvale
- Ebensburg
- Economy
- Eddystone
- Edgeworth
- Edinboro
- Edwardsville
- Ehrenfeld
- Elco